New medication for metastatic colorectal cancer approved
Lonsurf® (Trifluridin/Tipiracil) got in 05/2016 approval in treatment of advanced metastatic colorectal cancer. Lonsurf® is indicated, when all other conventional therapys (chemotherapy/antibodytherapy) failed. In studies Lonsurf® was compared with BSC (best supportiv care) and showed a positive influence in overall survival of the patients.
Literature: Yoshino T, Mizunuma N, Yamazaki K et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a doubleblind, randomised, placebo-controlled phase 2 trial. Lancet Oncol 13: 993-1001, 2012. DOI: 10.1016/S1470-2045(12)70345-5
Mayer R, Van Cutsem E, Falcone A et al.: Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med 372:1909-1919, 2015. DOI: 10.1056/NEJMoa1414325